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Carbonel AA, Simoes RS, Santos RH, Baracat MC, Simoes Mde J, Baracat EC, et al

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14,16 High iodine intake has been shown to provoke autoimmunity in animal models with a predisposition, and this corroborates the epidemiological data demonstrating a high incidence of Hashimotos thyroiditis and earlier onset of Graves disease in regions of high iodine intake

It has been revealed that thyroid cell lines that express both BRAF and RET/PTC can provoke genes that encode immune system response molecules, such as chemokines, which are pivotal for the early stages of HT lymphocytic infiltration